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Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect wasn't observed with istradefylline 20 mg/working day. Consider dose reduction of sensitive CYP3A4 substrates.If coadministration of CYP3A4 inhibitors with fentanyl is critical, monitor patients for respiratory depression and sedation at Repe